Alcohol intake trajectories during the life course and risk of alcohol-related cancer: A prospective cohort study

JK Bassett; RJ MacInnis; Y Yang; AM Hodge; BM Lynch; DR English; GG Giles; RL Milne; H Jayasekara

Journal article

Alcohol intake trajectories during the life course and risk of alcohol-related cancer: A prospective cohort study

JK Bassett, RJ MacInnis, Y Yang, AM Hodge, BM Lynch, DR English, GG Giles, RL Milne, H Jayasekara

International Journal of Cancer | WILEY | Published : 2022

DOI: 10.1002/ijc.33973

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Abstract

We examined associations between sex-specific alcohol intake trajectories and alcohol-related cancer risk using data from 22 756 women and 15 701 men aged 40 to 69 years at baseline in the Melbourne Collaborative Cohort Study. Alcohol intake for 10-year periods from age 20 until the decade encompassing recruitment, calculated using recalled beverage-specific frequency and quantity, was used to estimate group-based sex-specific intake trajectories. Hazard ratios (HR) and 95% confidence intervals (CI) were estimated for primary invasive alcohol-related cancer (upper aerodigestive tract, breast, liver and colorectum). Three distinct alcohol intake trajectories for women (lifetime abstention, st..

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University of Melbourne Researchers

Robert MacInnis Author

Yi Yang Author

Allison Hodge Author

Brigid Lynch Author

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Awarded by VicHealth

Funding Acknowledgements

MCCS cohort recruitment was funded by Cancer Council Victoria (https://www.cancervic.org.au/) and VicHealth (https://www.vichealth.vic.gov.au/).The MCCS was further supported by Australian National Health and Medical Research Council (NHMRC) (https://www.nhmrc.gov.au/) grants 209057, 396414 and 1074383, and ongoing follow-up and data management has been funded by Cancer Council Victoria since 1995. Cases and their vital status were ascertained through the Victorian Cancer Registry and the Australian Institute of Health and Welfare, including the National Death Index and the Australian Cancer Database. HJ is supported by NHMRC grant GNT1163120. BML is supported by a Mid-Career Fellowship from the Victorian Cancer Agency (MCRF1 8005). The sponsors had no role in the design and conduct of the study; collection, management, analysis and interpretation of the data; preparation, review or approval of the article; and decision to submit the article for publication.